Signaling with Increased Nigrostriatal Damage: Relevance to Parkinson’s Disease

Malva sylvestris aqueous extract could ameliorate 6-hydroxydopamine-induced motor asymmetry with no protective effect on dopaminergic nigrostriatal neurons in the rat

Background and Objective: Parkinson’s disease (PD) is a common neurological disorder due to degeneration of dopaminergic neurons within pars compacta of substantia nigra (SNC). With regard to protective effect of Malva sylvestris (MS), this study was conducted to evaluate the effect of aquaeous extract of this plant in an experimental model of PD induced by 6-hydroxydopamine (6-OHDA). Material...

Nigrostriatal Damage Preferentially Decreases a Subpopulation of α6β2* nAChRs in Mouse, Monkey and Parkinson’s Disease Striatum

Vulnerability of I-a-Conotoxin MII Binding Sites to Nigrostriatal Damage in Monkey

Parkinson’s disease, a neurodegenerative movement disorder characterized by selective degeneration of nigrostriatal dopaminergic neurons, affects ;1% of the population over 50. Because nicotinic acetylcholine receptors (nAChRs) may represent an important therapeutic target for this disorder, we performed experiments to elucidate the subtypes altered with nigrostriatal damage in parkinsonian mon...

Decrease in 3*/ 6* Nicotinic Receptors but Not Nicotine- Evoked Dopamine Release in Monkey Brain after Nigrostriatal Damage

Nicotinic acetylcholine receptors (nAChRs) are decreased in the striata of patients with Parkinson’s disease (PD) or in experimental models after nigrostriatal damage. Because presynaptic nAChRs on striatal dopamine terminals mediate dopamine release, receptor loss may contribute to behavioral deficits in PD. The present experiments were done to determine whether nAChR function is affected by n...

Op-brai120198 3699..3711

Classical accounts of the pathophysiology of Parkinson’s disease have emphasized degeneration of dopaminergic nigrostriatal neurons with consequent dysfunction of cortico–striatal–thalamic loops. In contrast, post-mortem studies indicate that pathological changes in Parkinson’s disease (Lewy neurites and Lewy bodies) first appear primarily in the lower brainstem with subsequent progression to m...